Sam is a six-foot dog and Max is a three-foot hyperkinetic rabbity thing and together they are a pair of freelance detectives who have spent years protecting the streets from evildoers. Their previous adventures have been recorded in a series of comic books, a video game, and a TV cartoon series, but their caseload has been relatively light for the past few years until now.

Now, the city is the victim of a crime wave and Sam & Max battle a new foe in each episode of Sam & Max: Season 1.